Journal article
Prediction of Early Symptom Remission in Two Independent Samples of First-Episode Psychosis Patients Using Machine Learning
RF Soldatos, M Cearns, M Nielsen, C Kollias, LA Xenaki, P Stefanatou, I Ralli, S Dimitrakopoulos, A Hatzimanolis, I Kosteletos, II Vlachos, M Selakovic, S Foteli, N Nianiakas, L Mantonakis, TF Triantafyllou, A Ntigridaki, V Ermiliou, M Voulgaraki, E Psarra Show all
Schizophrenia Bulletin | OXFORD UNIV PRESS | Published : 2022
Abstract
Background: Validated clinical prediction models of short-Term remission in psychosis are lacking. Our aim was to develop a clinical prediction model aimed at predicting 4-6-week remission following a first episode of psychosis. Method: Baseline clinical data from the Athens First Episode Research Study was used to develop a Support Vector Machine prediction model of 4-week symptom remission in first-episode psychosis patients using repeated nested cross-validation. This model was further tested to predict 6-week remission in a sample of two independent, consecutive Danish first-episode cohorts. Results: Of the 179 participants in Athens, 120 were male with an average age of 25.8 years and a..
View full abstractGrants
Awarded by NHMRC Senior Principal Research Fellowship
Awarded by NHMRC L3 Investigator Grant
Awarded by Lundbeck Foundation
Awarded by National Health and Medical Research Council of Australia
Funding Acknowledgements
C.P. was supported by a NHMRC Senior Principal Research Fellowship (ID: 1105825), an NHMRC L3 Investigator Grant (1196508), and a grant from the Lundbeck Foundation (ID: R246-2016-3237). B.E. was supported by a grant from the Lundbeck Foundation (ID: R316-2019-191), and has received lecture fees and/or is part of Advisory Boards of BristolMyers Squibb, Boehringer Ingelheim, Eli Lilly, and Company, Janssen-Cilag, Otsuka Pharma Scandinavia AB, Takeda Pharmaceutical Company and Lundbeck Pharma A/S. B.G. received grants for the PECANS studies from the Lundbeck Foundation (IDs: R13-A1349, R25-A2701, and R155-2013-16337). R.F.S. was the recipient of the Greek Australian Fellowship through the Melbourne Neuropsychiatry Centre, The University of Melbourne. R.F.S. acknowledges the support of Ms Debbie Argyropoulos, Mr George Keskerides, AHEPA Melbourne and the Ithacan community of Melbourne. The authors have declared that there are no conflicts of interest in relation to the subject of this study.